297
1. Bennett TD, Argent AC, Sanchez-Pinto LN. Phoenix Criteria for Pediatric Sepsis and Septic Shock-Reply. JAMA. 2024;331(23):2050-2051. doi: 10.1001/jama.2024.8202.
2. Choudhary R, Sitaraman S, Choudhary A. Lactate clearance as the predictor of outcome in pediatric septic shock. J Emerg Trauma Shock 2017; 10:55-59. doi:10.4103/JETS.JETS_103_16
3. Davis AL, Carcillo JA, Aneja RK, et al. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Crit Care Med 2017; 45:1061-1093. doi:10.1097/CCM.0000000000002425
4. Dhanani S, Cox PN. Infectious syndromes in the pediatric intensive care unit. In: Fuhrman & Zimmerman's Pediatric Critical Care, 4th ed, Fuhrman BP, Zimmerman JJ (Eds), Elsevier Saunders, Philadelphia 2011. p.1336.
5. Downes KJ, Weiss SL, Gerber JS, et al. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. J Pediatric Infect Dis Soc 2017; 6:134-141. doi:10.1093/jpids/piw023
6. Gaines NN, Patel B, Williams EA, et al. Etiologies of septic shock in a pediatric emergency department population. Pediatr Infect Dis J 2012; 31:1203. doi:10.1097/INF.0b013e3182678ca9
7. Goldstein B, Giroir B, Randolph A, International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2. doi:10.1097/01.PCC.0000149131.72248.E6
8. Graciano AL, Balko JA, Rahn DS, et al. The Pediatric Multiple Organ Dysfunction Score (P-MODS): development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children. Crit Care Med 2005; 33:1484. doi:10.1097/01.ccm.0000170943.23633.47
9. Han YY, Carcillo JA, Dragotta MA, et al. Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome. Pediatrics 2003; 112:793. doi:10.1542/peds.112.4.793
10. Juskewitch JE, Prasad S, Salas CF, et al. Reliability of the identification of the systemic inflammatory response syndrome in critically ill infants and children. Pediatr Crit Care Med 2012; 13:e55. doi:10.1097/PCC.0b013e31822f177a
11. Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med 2011; 12:165. doi:10.1097/PCC.0b013e3181e28876
12. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003; 29:530. doi:10.1007/s00134-003-1662-x
13. Luaces-Cubells C, Mintegi S, García-García JJ, et al. Procalcitonin to detect invasive bacterial infection in non-toxic-appearing infants with fever without apparent source in the emergency department. Pediatr Infect Dis J 2012; 31:645. doi:10.1097/INF.0b013e31824dacf4
14. Lucignano B, Ranno S, Liesenfeld O, et al. Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol 2011; 49:2252. doi:10.1128/JCM.02460-10
15. Maniaci V, Dauber A, Weiss S, et al. Procalcitonin in young febrile infants for the detection of serious bacterial infections. Pediatrics 2008; 122:701. doi:10.1542/peds.2007-3503
16. Marshall JC, Reinhart K, International Sepsis Forum. Biomarkers of sepsis. Crit Care Med 2009; 37:2290. doi:10.1097/CCM.0b013e3181a02afc
17. Morin L, Hall M, de Souza D, et al. Pediatric Sepsis Definition Taskforce. The Current and Future State of Pediatric Sepsis Definitions: An International Survey. Pediatrics. 2022;149(6):e2021052565. doi: 10.1542/peds.2021-052565.
18. Paul R, Melendez E, Stack A, et al. Improving adherence to PALS septic shock guidelines. Pediatrics 2014; 133:e1358. doi:10.1542/peds.2013-3871
19. Richter RP. International Perspective on a Revised Pediatric Sepsis Definition. Pediatrics. 2022 Jun 1;149(6):e2022056410. doi: 10.1542/peds.2022-056410.
20. Rudd KE, Johnson SC, Agesa KM et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study The Lancet 2020; 395:200-11. doi:10.1016/S0140-6736(19)32989-7
21. Schlapbach LJ, Kissoon N. Defining Pediatric Sepsis. JAMA Pediatr. 2018;172(4):312-314. doi: 10.1001/jamapediatrics.2017.5208
22. Schlapbach LJ, MacLaren G, Festa M, et al. Prediction of pediatric sepsis mortality within 1 h of intensive care admission. Intensive Care Med 2017; 43:1085. doi:10.1007/s00134-017-4701-8
23. Schlapbach LJ, Straney L, Bellomo R, et al. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med 2018; 44:179. doi:10.1007/s00134-017-5021-8
24. Schlapbach LJ, Watson RS, Sorce LR,et al.; Society of Critical Care Medicine Pediatric Sepsis Definition Task Force. International Consensus Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024 Feb 27;331(8):665-674. doi: 10.1001/jama.2024.0179.
25. Scott HF, Brou L, Deakyne SJ, et al. Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children. JAMA Pediatr 2017; 171:249. doi:10.1001/jamapediatrics.2016.3681
26. Tan B, Wong JJ, Sultana R, et al. Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis. JAMA Pediatr 2019; 173:352. doi:10.1001/jamapediatrics.2018.4839
27. The ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN). Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA. 2025;334(22):1988–1999. doi:10.1001/jama.2025.20402
28. Walker SB, Lockwood JM, Scott HF, et al. We Have New Sepsis Criteria for Children…Now What? Hosp Pediatr. 2025 Jul 1;15(7):e315-e317. doi: 10.1542/hpeds.2025-008421
29. Wang Y, Sun B, Yue H, et al. An epidemiologic survey of pediatric sepsis in regional hospitals in China. Pediatr Crit Care Med 2014; 15:814. doi:10.1097/PCC.0000000000000247
30. Weiss SL, Fitzgerald JC, Pappachan J, et al. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med. 2015;191(10):1147-1157. doi:10.1164/rccm.201412-2323OC
31. Weiss SL, Fitzgerald JC. Pediatric Sepsis Diagnosis, Management, and Sub-phenotypes. Pediatrics. 2024 Jan 1;153(1):e2023062967. doi: 10.1542/peds.2023-062967.
32. Weiss SL, Parker B, Bullock ME, et al. Defining pediatric sepsis by different criteria: discrepancies in populations and implications for clinical practice. Pediatr Crit Care Med 2012; 13:e219. doi:10.1097/PCC.0b013e31823c98da
33. Zaoutis TE, Prasad PA, Localio AR, et al. Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention. Clin Infect Dis 2010; 51:e38. doi:10.1086/655698