99
1. American Academy of Pediatrics. Fever without a source in infants and children. In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, eds. Red Book: 2024-2027 Report of the Committee on Infectious Diseases. 33rd ed. Itasca, IL: American Academy of Pediatrics; 2024: 829-834.
2. Antoon JW, Potisek NM, Lohr JA. Pediatric fever of unknown origin. Pediatr Rev. Sep 2015;36(9):380-390; quiz 391. doi:10.1542/pir.36-9-380
3. Baker MD. Fever without a source. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, eds. Principles and Practice of Pediatric Infectious Diseases. 6th ed. Philadelphia, PA: Elsevier; 2022: 123-129.
4. Bansal S, Goyal A. Physiology, fever. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK562334/
5. Baraff LJ. Management of fever without source in infants and children. Ann Emerg Med. Dec 2000;36(6):602-614. doi:10.1067/mem.2000.110820
6. Basha S, Surendran N, Pichichero M. Immune responses in neonates. Expert Rev Clin Immunol. Sep 2014;10(9):1171-1184. doi:10.1586/1744666X.2014.942288
7. Bleeker-Rovers CP, Vos FJ, de Kleijn E, et al. A prospective multicenter study on fever of unknown origin: the yield of a structured diagnostic protocol. Medicine (Baltimore). Jan 2007;86(1):26-38. doi:10.1097/MD.0b013e31802fe858
8. Brisse E, Wouters CH, Matthys P. Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities. Br J Haematol. Jul 2016;174(2):203-217. doi:10.1111/bjh.14147
9. Byington CL, Enriquez FR, Hoff C, et al. Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections. Pediatrics. Jun 2004;113(6):1662-1666. doi:10.1542/peds.113.6.1662
10. Chow A, Robinson JL. Fever of unknown origin in children: a systematic review. World J Pediatr. Feb 2011;7(1):5-10. doi:10.1007/s12519-011-0240-5
11. Chusid MJ. Fever of unknown origin in childhood. Pediatr Clin North Am. Feb 2017;64(1):205-230. doi:10.1016/j.pcl.2016.08.014
12. Crump JA, Mintz ED. Global trends in typhoid and paratyphoid fever. Clin Infect Dis. Jan 2010;50(2):241-246. doi:10.1086/649541
13. Evans SS, Repasky EA, Fisher DT. Fever and thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol. Jun 2015;15(6):335-349. doi:10.1038/nri3843
14. Federici S, Caorsi R, Gattorno M. The autoinflammatory diseases. Swiss Med Wkly. 2012;142:w13602. doi:10.4414/smw.2012.13602
15. Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis. Feb 2011;52(4):427-431. doi:10.1093/cid/ciq147
16. Galetto-Lacour A, Zamora SA, Gervaix A. Bedside procalcitonin and CRP tests in children with fever without localizing signs of infection seen in a referral center. Pediatrics. Nov 2003;112(5):1054-1060. doi:10.1542/peds.112.5.1054
17. Gomez B, Bressan S, Mintegi S, et al. Diagnostic value of procalcitonin in well-appearing young febrile infants. Pediatrics. Nov 2012;130(5):815-822. doi:10.1542/peds.2011-3575
18. Graaf S, Keuning MW, Pajkrt D, Plotz FB. Fever without source in children: international comparison of guidelines. World J Pediatr. Feb 2023;19(2):120-128. doi:10.1007/s12519-022-00611-8
19. Graf T, Malay S, Frank E. Rate of urinary tract infections, bacteremia, and meningitis in preterm and term infants. Pediatrics. Apr 2024;153(4). doi:10.1542/peds.2023-062755
20. Greenhow TL, Hung YY, Herz A. Bacteremia in children 3 to 36 months old after introduction of conjugated pneumococcal vaccines. Pediatrics. Apr 2017;139(4). doi:10.1542/peds.2016-2098
21. Greenhow TL, Hung YY, Herz AM. Changing epidemiology of bacteremia in infants aged 1 week to 3 months. Pediatrics. Mar 2012;129(3):e590-e596. doi:10.1542/peds.2011-1546
22. Grohskopf LA, Alyanak E, Broder KR, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2019-20 Influenza Season. MMWR Recomm Rep. Aug 2019;68(3):1-21. doi:10.15585/mmwr.rr6803a1
23. Groll AH, Castagnola E, Cesaro S, et al. ECIL-4 guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. Lancet Oncol. Jul 2014;15(8):e327-e340. doi:10.1016/S1470-2045(14)70017-8
24. Gu W, Miller S, Chiu CY. Clinical metagenomic next-generation sequencing for pathogen detection. Annu Rev Pathol. Jan 2019;14:319-338. doi:10.1146/annurev-pathmechdis-012418-012751
25. Hamilton JL, John SP. Evaluation of fever in infants and young children. Am Fam Physician. 2013;87(4):254-260.
26. Hu B, Chen TM, Liu SP, et al. Fever of unknown origin in children: Beijing experience. BMJ Open. Mar 2022;12(3):e049840. doi:10.1136/bmjopen-2021-049840
27. Huang YC, Liu MF, Shen GH, et al. Clinical outcome of Mycobacterium abscessus infection and antimicrobial susceptibility testing. J Microbiol Immunol Infect. Oct 2010;43(5):401-406. doi:10.1016/S1684-1182(10)60063-1
28. Kim YS, Kang JM, Kim JM, Kim YJ. Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center. Korean J Pediatr. 2017;60(3):77-85. doi:10.3345/kjp.2017.60.3.77
29. Kuppermann N, Fleisher GR, Jaffe DM. Predictors of occult pneumococcal bacteremia in young febrile children. Ann Emerg Med. Jun 1998;31(6):679-687. doi:10.1016/s0196-0644(98)70225-2
30. L’Huillier AG, Mardegan C, Cordey S, et al. Enterovirus, parechovirus, adenovirus and herpes virus type 6 viraemia in fever without source fever without source. Arch Dis Child. Feb 2020;105(2):180-186. doi:10.1136/archdischild-2019-317382
31. Leazer RC. Evaluation and management of young febrile ınfants: an overview of the new AAP guideline. Pediatr Rev. Mar 2023;44(3):127-138. doi:10.1542/pir.2022-005624
32. Lee CC, Cheng SY, Chang IJ, et al. Serious bacterial infections in young children with fever without source after discharge from emergency department: a National Health Insurance database cohort study. Pediatr Neonatol. 2022;63(5):527-534. doi: 10.1016/j.pedneo.2022.03.020.
33. Lehrnbecher T, Phillips R. Fever and neutropenia in children with cancer. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia, PA: Wolters Kluwer; 2016: 1239-1254.
34. Lehrnbecher T, Robinson P, Fisher B, et al. Guideline for management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update. J Clin Oncol. Jun 2017;35(18):2082-2094. doi:10.1200/JCO.2016.71.7017
35. Lehrnbecher T, Robinson PD, Ammann RA, et al. guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2023 Update. J Clin Oncol. Mar 2023;41(9):1774-1785. doi:10.1200/JCO.22.02224
36. Lehrnbecher T, Sung L, Phillips R. Infections in children with cancer. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia, PA: Wolters Kluwer; 2016: 1190-1215.
37. Mackowiak PA. Concepts of fever. Arch Intern Med. Sep 1998;158(17):1870-1881. doi:10.1001/archinte.158.17.1870
38. Mahajan P, Kuppermann N, Mejias A, et al. Association of RNA biosignatures with bacterial infections in febrile infants aged 60 days or younger. JAMA. Aug 2016;316(8):846-857. doi:10.1001/jama.2016.9207
39. Marks M, Solomon AW, Mabey DC. Endemic treponemal diseases. Trans R Soc Trop Med Hyg. Oct 2014;108(10):601-607. doi:10.1093/trstmh/tru128
40. Mussap M, Puxeddu E, Burrai P, et al. Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges. J Matern Fetal Neonatal Med. Oct 2012;25(Suppl 5):51-53. doi:10.3109/14767058.2012.717462
41. National Institute for Health and Care Excellence (NICE). Evidence review for signs and symptoms predicting Kawasaki disease. In: NICE Evidence Reviews Collection. London, UK: National Institute for Health and Care Excellence; 2019. https://www.ncbi.nlm.nih.gov/books/
42. Nijman RG, Vergouwe Y, Thompson M, et al. Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study. BMJ. Apr 2013;346:f1706. doi:10.1136/bmj.f1706
43. Ozen S, Bilginer Y. A clinical guide to autoinflammatory diseases: familial mediterranean fever and next-of-kin. Nat Rev Rheumatol. Mar 2014;10(3):135-147. doi:10.1038/nrrheum.2013.174
44. Pantell RH, Roberts KB, Adams WG, et al. Evaluation and management of well-appearing febrile infants 8 to 60 days old. pediatrics. aug 2021;148(2). doi:10.1542/peds.2021-052228
45. Patel RA, Gallagher JC. Drug fever. Pharmacotherapy. Jan 2010;30(1):57-69. doi:10.1592/phco.30.1.57
46. Patel SJ, Newland JG. Advancing antimicrobial stewardship in a challenging era. J Pediatric Infect Dis Soc. Sep 2025. doi:10.1093/jpids/piaf082
47. Patel SJ, Saiman L. Principles and strategies of antimicrobial stewardship in NICU. Semin Perinatol. Dec 2012;36(6):431-436. doi:10.1053/j.semperi.2012.06.005
48. Santacroce L, Colella M, Charitos IA, et al. Microbial and host metabolites at the backstage of fever: current knowledge about the co-ordinate action of receptors and molecules underlying pathophysiology and clinical implications. Metabolites. Mar 2023;13(3):461. doi:10.3390/metabo13030461
49. Sedney CJ, Harvill ET. Neonatal immune system and respiratory pathogens. Microorganisms. Jun 2023;11(6). doi:10.3390/microorganisms11061597
50. Shoman W, Elshishiny AM, et al. Fever of unknown origin in pediatrics. Egypt Pediatr Assoc Gaz. 2024;72:65. doi:10.1186/s43054-024-00307-w
51. Tran XD, Hoang VT, Dang TTD, et al. Aetiology of acute undifferentiated fever among children under the age of five in Vietnam: a prospective study. J Epidemiol Glob Health. Jun 2023;13(2):163-172. Doi:10.1007/s44197-023-00121-4
52. Trapani S, Fiordelisi A, Stinco M, Resti M. Update on FUO in children : focus on etiologies and clinical approach. Children (Basel). Dec 2023;11(1). doi:10.3390/children11010020
53. van Rijsewijk ND, IJpma FF, Wouthuyzen-Bakker M, et al. Molecular imaging of FUO: An Update. Semin Nucl Med. 2023;53(1):4-17. doi:10.1053/j.semnuclmed.2022.07.002
54. van Rossum AM, Wulkan RW, Oudesluys-Murphy AM. Procalcitonin as an early marker of infection in neonates and children. Lancet Infect Dis. Oct 2004;4(10):620-630. doi:10.1016/S1473-3099(04)01146-6
55. Watt JP, Levine OS, Santosham M. Global reduction of Hib disease : what are the next steps? Proceedings of the meeting Scottsdale, Arizona, September 22-25, 2002. J Pediatr. Dec 2003;143(6 Suppl):S163-S187. doi:10.1067/s0022-3476(03)00576-6
56. Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. Feb 2020;21(2):e52-e106. doi:10.1097/PCC.0000000000002198
57. Yo CH, Hsieh PS, Lee SH, et al. Comparison of the test characteristics of procalcitonin to C-reactive protein and leukocytosis for the detection of serious bacterial infections in children presenting with fever without source: a systematic review and meta-analysis. Ann Emerg Med. Nov 2012;60(5):591-600. doi:10.1016/j.annemergmed.2012.05.027